Drug interactions
Lurasidone + Zaleplon
Severity: Moderate
Lurasidone and Zaleplon: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lurasidone is sedating and zaleplon is a hypnotic, so combined use may deepen drowsiness and impair alertness and coordination. The risk of falls and next-day impairment rises, particularly in the elderly.
What this interaction means in plain words
Lurasidone and Zaleplon can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lurasidone belongs to Central Nervous System; Zaleplon belongs to Central Nervous System.
Why it happens
Additive CNS depressant effects of the two agents.
What to do
Start with the lowest effective zaleplon dose and monitor for oversedation, dizziness and falls. Advise patients not to drive until the response is known.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Zaleplon
- Calcium / magnesium / potassium / sodium oxybates + Zaleplon Contraindicated
- Sodium oxybate + Zaleplon Contraindicated
- Brexanolone + Zaleplon Major
- Buprenorphine long-acting + Zaleplon Major
- Buprenorphine subdermal implant + Zaleplon Major
- Buprenorphine transdermal + Zaleplon Major
Other interactions of Lurasidone
- Apalutamide + Lurasidone Contraindicated
- Atazanavir + Lurasidone Contraindicated
- Carbamazepine + Lurasidone Contraindicated
- Clarithromycin + Lurasidone Contraindicated
- Cobicistat + Lurasidone Contraindicated
- Conivaptan + Lurasidone Contraindicated
Frequently asked questions
Can I take Lurasidone with Zaleplon?
MediHelp rates the interaction as moderate. Lurasidone and Zaleplon can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lurasidone is sedating and zaleplon is a hypnotic, so combined use may deepen drowsiness and impair alertness and coordination. The risk of falls and next-day impairment rises, particularly in the elderly.
How serious is the interaction between Lurasidone and Zaleplon?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start with the lowest effective zaleplon dose and monitor for oversedation, dizziness and falls. Advise patients not to drive until the response is known.
What other medicines interact with Zaleplon?
MediHelp also lists interactions of Zaleplon with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Brexanolone. The full list is on the Zaleplon page.
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