Drug interactions
Lurasidone + Zolpidem
Severity: Moderate
Lurasidone and Zolpidem: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lurasidone can cause somnolence and, with zolpidem, may increase sedation and impair psychomotor performance. Falls and next-day impairment are the main concerns.
What this interaction means in plain words
Lurasidone and Zolpidem can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Lurasidone belongs to Central Nervous System; Zolpidem belongs to Central Nervous System.
Why it happens
Additive CNS depression via GABA-A potentiation and antipsychotic receptor antagonism.
What to do
Use the lowest effective zolpidem dose and monitor for daytime sedation and orthostatic symptoms. Advise caution with driving.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Zolpidem
Other interactions of Lurasidone
- Apalutamide + Lurasidone Contraindicated
- Atazanavir + Lurasidone Contraindicated
- Carbamazepine + Lurasidone Contraindicated
- Clarithromycin + Lurasidone Contraindicated
- Cobicistat + Lurasidone Contraindicated
- Conivaptan + Lurasidone Contraindicated
Frequently asked questions
Can I take Lurasidone with Zolpidem?
MediHelp rates the interaction as moderate. Lurasidone and Zolpidem can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lurasidone can cause somnolence and, with zolpidem, may increase sedation and impair psychomotor performance. Falls and next-day impairment are the main concerns.
How serious is the interaction between Lurasidone and Zolpidem?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective zolpidem dose and monitor for daytime sedation and orthostatic symptoms. Advise caution with driving.
What other medicines interact with Zolpidem?
MediHelp also lists interactions of Zolpidem with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Benzhydrocodone / acetaminophen. The full list is on the Zolpidem page.
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