Drug interactions
Lycopus + Rosiglitazone
Severity: Minor
Lycopus and Rosiglitazone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lycopus (bugleweed) has been reported in preclinical work to affect glucose and thyroid hormone activity. Combined with rosiglitazone it could theoretically enhance glucose lowering and increase the risk of hypoglycemia.
What this interaction means in plain words
Lycopus and Rosiglitazone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Theoretical additive hypoglycemic effect; mechanism not established.
What to do
Monitor blood glucose when starting or stopping lycopus products in a patient on rosiglitazone. Reduce the antidiabetic dose only if hypoglycemia occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Rosiglitazone
- Insulin aspart protamine / insulin aspart + Rosiglitazone Major
- Insulin aspart-insulin aspart protamine + Rosiglitazone Major
- Insulin aspart + Rosiglitazone Major
- Insulin degludec / insulin aspart + Rosiglitazone Major
- Insulin degludec-insulin aspart + Rosiglitazone Major
- Insulin degludec-liraglutide + Rosiglitazone Major
Frequently asked questions
Can I take Lycopus with Rosiglitazone?
MediHelp rates the interaction as minor. Lycopus and Rosiglitazone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Lycopus (bugleweed) has been reported in preclinical work to affect glucose and thyroid hormone activity. Combined with rosiglitazone it could theoretically enhance glucose lowering and increase the risk of hypoglycemia.
How serious is the interaction between Lycopus and Rosiglitazone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when starting or stopping lycopus products in a patient on rosiglitazone. Reduce the antidiabetic dose only if hypoglycemia occurs.
What other medicines interact with Rosiglitazone?
MediHelp also lists interactions of Rosiglitazone with, for example, Insulin aspart protamine / insulin aspart, Insulin aspart-insulin aspart protamine, Insulin aspart. The full list is on the Rosiglitazone page.
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