Drug interactions
Macimorelin + Olanzapine
Severity: Moderate
Macimorelin and Olanzapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Macimorelin causes a small QT increase, and olanzapine may add to it. The risk is mainly relevant during the single-dose diagnostic test.
What this interaction means in plain words
Macimorelin and Olanzapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Macimorelin belongs to Endocrine; Olanzapine belongs to Central Nervous System.
Why it happens
Additive prolongation of the QT interval.
What to do
Where clinically possible, withhold olanzapine for a suitable washout period before the macimorelin test. Otherwise consider an ECG and correct electrolytes.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Olanzapine
Other interactions of Macimorelin
Frequently asked questions
Can I take Macimorelin with Olanzapine?
MediHelp rates the interaction as moderate. Macimorelin and Olanzapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Macimorelin causes a small QT increase, and olanzapine may add to it. The risk is mainly relevant during the single-dose diagnostic test.
How serious is the interaction between Macimorelin and Olanzapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Where clinically possible, withhold olanzapine for a suitable washout period before the macimorelin test. Otherwise consider an ECG and correct electrolytes.
What other medicines interact with Olanzapine?
MediHelp also lists interactions of Olanzapine with, for example, Amisulpride, Amoxapine, Apomorphine. The full list is on the Olanzapine page.
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