Drug interactions
Macimorelin + Pimozide
Severity: Major
Macimorelin and Pimozide: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs prolong the QT interval, so combining them raises the risk of torsades de pointes. Pimozide is a high-risk QT drug and macimorelin is used as a diagnostic test where this risk can be avoided.
What this interaction means in plain words
Macimorelin and Pimozide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Macimorelin belongs to Endocrine; Pimozide belongs to Central Nervous System.
Why it happens
Additive pharmacodynamic QT prolongation through effects on cardiac repolarization.
What to do
Avoid the combination and allow adequate washout of pimozide before macimorelin testing, or use another diagnostic approach. Correct potassium and magnesium abnormalities beforehand.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Pimozide
- Adagrasib + Pimozide Contraindicated
- Amiodarone + Pimozide Contraindicated
- Amisulpride + Pimozide Contraindicated
- Amitriptyline + Pimozide Contraindicated
- Amoxapine + Pimozide Contraindicated
- Anagrelide + Pimozide Contraindicated
Other interactions of Macimorelin
Frequently asked questions
Can I take Macimorelin with Pimozide?
MediHelp rates the interaction as major. Macimorelin and Pimozide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs prolong the QT interval, so combining them raises the risk of torsades de pointes. Pimozide is a high-risk QT drug and macimorelin is used as a diagnostic test where this risk can be avoided.
How serious is the interaction between Macimorelin and Pimozide?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and allow adequate washout of pimozide before macimorelin testing, or use another diagnostic approach. Correct potassium and magnesium abnormalities beforehand.
What other medicines interact with Pimozide?
MediHelp also lists interactions of Pimozide with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Pimozide page.
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