Drug interactions
Macimorelin + Somatropin
Severity: Moderate
Macimorelin and Somatropin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Somatropin may interfere with the growth hormone response to macimorelin and compromise the accuracy of the diagnostic test. This could lead to a false interpretation of growth hormone status.
What this interaction means in plain words
Macimorelin and Somatropin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Macimorelin belongs to Endocrine; Somatropin belongs to Endocrine.
Why it happens
Exogenous growth hormone alters endogenous GH axis feedback, blunting the stimulated GH response measured in the test.
What to do
Stop somatropin at least one week before macimorelin testing. Interpret results cautiously if this washout was not achieved.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Somatropin
- Acarbose + Somatropin Moderate
- Albiglutide + Somatropin Moderate
- Alogliptin-metformin + Somatropin Moderate
- Alogliptin-pioglitazone + Somatropin Moderate
- Alogliptin + Somatropin Moderate
- Betamethasone + Somatropin Moderate
Other interactions of Macimorelin
Frequently asked questions
Can I take Macimorelin with Somatropin?
MediHelp rates the interaction as moderate. Macimorelin and Somatropin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Somatropin may interfere with the growth hormone response to macimorelin and compromise the accuracy of the diagnostic test. This could lead to a false interpretation of growth hormone status.
How serious is the interaction between Macimorelin and Somatropin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Stop somatropin at least one week before macimorelin testing. Interpret results cautiously if this washout was not achieved.
What other medicines interact with Somatropin?
MediHelp also lists interactions of Somatropin with, for example, Acarbose, Albiglutide, Alogliptin-metformin. The full list is on the Somatropin page.
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