Drug interactions
Macitentan + Nicardipine
Severity: Moderate
Macitentan and Nicardipine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Macitentan is metabolized by CYP3A4, and nicardipine may raise its concentrations modestly. Increased exposure could worsen hypotension, anemia and hepatic effects; additive blood pressure lowering is also expected.
What this interaction means in plain words
Macitentan and Nicardipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Macitentan belongs to Cardiovascular; Nicardipine belongs to Cardiovascular.
Why it happens
Nicardipine weakly inhibits CYP3A4, reducing macitentan clearance, and both drugs lower blood pressure.
What to do
Monitor blood pressure, hemoglobin and liver enzymes. Adjust the nicardipine dose if symptomatic hypotension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nicardipine
Other interactions of Macitentan
- Amiodarone + Macitentan Major
- Apalutamide + Macitentan Major
- Bosentan + Macitentan Major
- Carbamazepine + Macitentan Major
- Clarithromycin + Macitentan Major
- Efavirenz + Macitentan Major
Frequently asked questions
Can I take Macitentan with Nicardipine?
MediHelp rates the interaction as moderate. Macitentan and Nicardipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Macitentan is metabolized by CYP3A4, and nicardipine may raise its concentrations modestly. Increased exposure could worsen hypotension, anemia and hepatic effects; additive blood pressure lowering is also expected.
How serious is the interaction between Macitentan and Nicardipine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, hemoglobin and liver enzymes. Adjust the nicardipine dose if symptomatic hypotension occurs.
What other medicines interact with Nicardipine?
MediHelp also lists interactions of Nicardipine with, for example, Amifostine, Amlodipine-olmesartan-hydrochlorothiazide, Betrixaban. The full list is on the Nicardipine page.
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