Drug interactions
Macitentan + Quinidine
Severity: Moderate
Macitentan and Quinidine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Macitentan is metabolized mainly by CYP3A4, and quinidine is a CYP3A4 inhibitor, though weaker than agents like ketoconazole. Exposure to macitentan may increase modestly, raising the risk of adverse effects such as anemia, hypotension, and edema.
What this interaction means in plain words
Macitentan and Quinidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Macitentan belongs to Cardiovascular; Quinidine belongs to Anti Parasitic.
Why it happens
Quinidine inhibits CYP3A4, reducing macitentan clearance.
What to do
Monitor blood pressure and hemoglobin when used together. Reassess if adverse effects appear.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Quinidine
- Adagrasib + Quinidine Contraindicated
- Arsenic trioxide + Quinidine Contraindicated
- Artemether / lumefantrine + Quinidine Contraindicated
- Chloroquine + Quinidine Contraindicated
- Dofetilide + Quinidine Contraindicated
- Dronedarone + Quinidine Contraindicated
Other interactions of Macitentan
- Amiodarone + Macitentan Major
- Apalutamide + Macitentan Major
- Bosentan + Macitentan Major
- Carbamazepine + Macitentan Major
- Clarithromycin + Macitentan Major
- Efavirenz + Macitentan Major
Frequently asked questions
Can I take Macitentan with Quinidine?
MediHelp rates the interaction as moderate. Macitentan and Quinidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Macitentan is metabolized mainly by CYP3A4, and quinidine is a CYP3A4 inhibitor, though weaker than agents like ketoconazole. Exposure to macitentan may increase modestly, raising the risk of adverse effects such as anemia, hypotension, and edema.
How serious is the interaction between Macitentan and Quinidine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and hemoglobin when used together. Reassess if adverse effects appear.
What other medicines interact with Quinidine?
MediHelp also lists interactions of Quinidine with, for example, Adagrasib, Arsenic trioxide, Artemether / lumefantrine. The full list is on the Quinidine page.
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