Drug interactions
Magnesium + Spironolactone
Severity: Minor
Magnesium and Spironolactone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Spironolactone is a potassium-sparing diuretic that causes little urinary magnesium loss and may modestly conserve magnesium. Any rise in serum magnesium is small and rarely matters except in patients with advanced renal impairment receiving large magnesium doses.
What this interaction means in plain words
Magnesium and Spironolactone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Magnesium belongs to Gastrointestinal Tract; Spironolactone belongs to Cardiovascular.
Why it happens
Reduced renal magnesium excretion through aldosterone antagonism in the distal nephron is proposed but poorly characterized.
What to do
No routine action is needed. Check serum magnesium in patients with renal impairment who are receiving high-dose magnesium together with spironolactone.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Magnesium
- Ciprofloxacin + Magnesium Major
- Magnesium + Pancuronium Major
- Magnesium + Rocuronium Major
- Magnesium + Vecuronium Major
- Amikacin + Magnesium Moderate
- Amphotericin b deoxycholate + Magnesium Moderate
Other interactions of Spironolactone
- Amiloride + Spironolactone Contraindicated
- Eplerenone + Spironolactone Contraindicated
- Spironolactone + Triamterene Contraindicated
- Abiraterone + Spironolactone Major
- Aceclofenac + Spironolactone Major
- Acemetacin + Spironolactone Major
Frequently asked questions
Can I take Magnesium with Spironolactone?
MediHelp rates the interaction as minor. Magnesium and Spironolactone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Spironolactone is a potassium-sparing diuretic that causes little urinary magnesium loss and may modestly conserve magnesium. Any rise in serum magnesium is small and rarely matters except in patients with advanced renal impairment receiving large magnesium doses.
How serious is the interaction between Magnesium and Spironolactone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine action is needed. Check serum magnesium in patients with renal impairment who are receiving high-dose magnesium together with spironolactone.
What other medicines interact with Magnesium?
MediHelp also lists interactions of Magnesium with, for example, Ciprofloxacin, Pancuronium, Rocuronium. The full list is on the Magnesium page.
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