Drug interactions
Magnesium + Streptomycin
Severity: Moderate
Magnesium and Streptomycin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Aminoglycosides can cause renal magnesium wasting, which may lower serum magnesium during prolonged therapy. Separately, magnesium can add to the neuromuscular blocking effect of aminoglycosides, which matters most with parenteral magnesium sulfate.
What this interaction means in plain words
Magnesium and Streptomycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Magnesium belongs to Gastrointestinal Tract; Streptomycin belongs to Anti Bacterial.
Why it happens
Aminoglycoside-induced tubular injury increases urinary magnesium loss, and both agents impair neuromuscular transmission at the junction.
What to do
Monitor serum magnesium during aminoglycoside therapy and replace as needed. Watch for respiratory depression and muscle weakness when parenteral magnesium is given at the same time.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Magnesium and Streptomycin, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Magnesium
- Ciprofloxacin + Magnesium Major
- Magnesium + Pancuronium Major
- Magnesium + Rocuronium Major
- Magnesium + Vecuronium Major
- Amikacin + Magnesium Moderate
- Amphotericin b deoxycholate + Magnesium Moderate
Other interactions of Streptomycin
Frequently asked questions
Can I take Magnesium with Streptomycin?
MediHelp rates the interaction as moderate. Magnesium and Streptomycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Aminoglycosides can cause renal magnesium wasting, which may lower serum magnesium during prolonged therapy. Separately, magnesium can add to the neuromuscular blocking effect of aminoglycosides, which matters most with parenteral magnesium sulfate.
How serious is the interaction between Magnesium and Streptomycin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum magnesium during aminoglycoside therapy and replace as needed. Watch for respiratory depression and muscle weakness when parenteral magnesium is given at the same time.
What other medicines interact with Magnesium?
MediHelp also lists interactions of Magnesium with, for example, Ciprofloxacin, Pancuronium, Rocuronium. The full list is on the Magnesium page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
