Drug interactions
Magnesium sulfate + Moxifloxacin
Severity: Moderate
Magnesium sulfate and Moxifloxacin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oral magnesium sulfate can bind moxifloxacin in the gut and reduce absorption. Intravenous magnesium sulfate does not cause this chelation effect.
What this interaction means in plain words
Magnesium sulfate and Moxifloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Chelation of moxifloxacin by magnesium cations in the gastrointestinal tract.
What to do
With oral magnesium sulfate, take oral moxifloxacin at least 4 hours before or 8 hours after. No separation is needed for intravenous magnesium.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Moxifloxacin
- Amiodarone + Moxifloxacin Contraindicated
- Arsenic trioxide + Moxifloxacin Contraindicated
- Disopyramide + Moxifloxacin Contraindicated
- Dofetilide + Moxifloxacin Contraindicated
- Dronedarone + Moxifloxacin Contraindicated
- Droperidol + Moxifloxacin Contraindicated
Frequently asked questions
Can I take Magnesium sulfate with Moxifloxacin?
MediHelp rates the interaction as moderate. Magnesium sulfate and Moxifloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Oral magnesium sulfate can bind moxifloxacin in the gut and reduce absorption. Intravenous magnesium sulfate does not cause this chelation effect.
How serious is the interaction between Magnesium sulfate and Moxifloxacin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: With oral magnesium sulfate, take oral moxifloxacin at least 4 hours before or 8 hours after. No separation is needed for intravenous magnesium.
What other medicines interact with Moxifloxacin?
MediHelp also lists interactions of Moxifloxacin with, for example, Amiodarone, Arsenic trioxide, Disopyramide. The full list is on the Moxifloxacin page.
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