Drug interactions
Magnesium supplement + Moxifloxacin
Severity: Moderate
Magnesium supplement and Moxifloxacin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Magnesium binds moxifloxacin in the gut and forms insoluble complexes, which reduces absorption. This can lead to subtherapeutic antibiotic levels and treatment failure.
What this interaction means in plain words
Magnesium supplement and Moxifloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Chelation of moxifloxacin by divalent magnesium cations in the gastrointestinal tract, reducing absorption.
What to do
Give moxifloxacin at least 4 hours before or 8 hours after magnesium supplements.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Moxifloxacin
- Amiodarone + Moxifloxacin Contraindicated
- Arsenic trioxide + Moxifloxacin Contraindicated
- Disopyramide + Moxifloxacin Contraindicated
- Dofetilide + Moxifloxacin Contraindicated
- Dronedarone + Moxifloxacin Contraindicated
- Droperidol + Moxifloxacin Contraindicated
Frequently asked questions
Can I take Magnesium supplement with Moxifloxacin?
MediHelp rates the interaction as moderate. Magnesium supplement and Moxifloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Magnesium binds moxifloxacin in the gut and forms insoluble complexes, which reduces absorption. This can lead to subtherapeutic antibiotic levels and treatment failure.
How serious is the interaction between Magnesium supplement and Moxifloxacin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give moxifloxacin at least 4 hours before or 8 hours after magnesium supplements.
What other medicines interact with Moxifloxacin?
MediHelp also lists interactions of Moxifloxacin with, for example, Amiodarone, Arsenic trioxide, Disopyramide. The full list is on the Moxifloxacin page.
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