Drug interactions
Maitake + Sirolimus
Severity: Minor
Maitake and Sirolimus: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Maitake is claimed to stimulate immune function, which could oppose sirolimus immunosuppression. The effect is unproven and clinical data are lacking.
What this interaction means in plain words
Maitake and Sirolimus have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Theoretical pharmacodynamic opposition from immune-stimulating polysaccharides; not established.
What to do
Advise transplant patients against using maitake supplements, or monitor for graft dysfunction if the patient takes them.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Sirolimus
- Adenovirus types 4 and 7 live + Sirolimus Contraindicated
- Bcg vaccine live + Sirolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Sirolimus Contraindicated
- Ketoconazole + Sirolimus Contraindicated
- Levoketoconazole + Sirolimus Contraindicated
- Measles mumps and rubella vaccine live + Sirolimus Contraindicated
Frequently asked questions
Can I take Maitake with Sirolimus?
MediHelp rates the interaction as minor. Maitake and Sirolimus have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Maitake is claimed to stimulate immune function, which could oppose sirolimus immunosuppression. The effect is unproven and clinical data are lacking.
How serious is the interaction between Maitake and Sirolimus?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise transplant patients against using maitake supplements, or monitor for graft dysfunction if the patient takes them.
What other medicines interact with Sirolimus?
MediHelp also lists interactions of Sirolimus with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Sirolimus page.
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