Drug interactions
Maprotiline + Metformin-pioglitazone
Severity: Minor
Maprotiline and Metformin-pioglitazone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Maprotiline, a tetracyclic antidepressant, may alter glucose control and has rarely been linked to changes in glycemia in diabetic patients. The effect is inconsistent and usually small.
What this interaction means in plain words
Maprotiline and Metformin-pioglitazone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Maprotiline belongs to Central Nervous System; Metformin-pioglitazone belongs to Endocrine.
Why it happens
Mechanism is not well established; may involve effects on insulin secretion, appetite and weight.
What to do
Monitor blood glucose when maprotiline is started or stopped and adjust antidiabetic therapy if needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Metformin-pioglitazone
Other interactions of Maprotiline
- Arsenic trioxide + Maprotiline Contraindicated
- Disopyramide + Maprotiline Contraindicated
- Dofetilide + Maprotiline Contraindicated
- Ibutilide + Maprotiline Contraindicated
- Isocarboxazid + Maprotiline Contraindicated
- Maprotiline + Methylene blue Contraindicated
Frequently asked questions
Can I take Maprotiline with Metformin-pioglitazone?
MediHelp rates the interaction as minor. Maprotiline and Metformin-pioglitazone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Maprotiline, a tetracyclic antidepressant, may alter glucose control and has rarely been linked to changes in glycemia in diabetic patients. The effect is inconsistent and usually small.
How serious is the interaction between Maprotiline and Metformin-pioglitazone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when maprotiline is started or stopped and adjust antidiabetic therapy if needed.
What other medicines interact with Metformin-pioglitazone?
MediHelp also lists interactions of Metformin-pioglitazone with, for example, Contrast media, Diatrizoate meglumine / diatrizoate, Diatrizoate. The full list is on the Metformin-pioglitazone page.
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