Drug interactions
Maprotiline + Nilotinib
Severity: Major
Maprotiline and Nilotinib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can prolong the QT interval, and nilotinib carries a boxed warning for QT prolongation and sudden death. Giving them together increases the risk of torsades de pointes and ventricular arrhythmia.
What this interaction means in plain words
Maprotiline and Nilotinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Maprotiline belongs to Central Nervous System; Nilotinib belongs to Oncology.
Why it happens
Additive blockade of cardiac repolarizing potassium currents (hERG) leading to QT prolongation.
What to do
Avoid the combination where possible and choose a non-QT-prolonging antidepressant. If unavoidable, obtain a baseline ECG, correct potassium and magnesium, and monitor the QTc regularly.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Maprotiline
- Arsenic trioxide + Maprotiline Contraindicated
- Disopyramide + Maprotiline Contraindicated
- Dofetilide + Maprotiline Contraindicated
- Ibutilide + Maprotiline Contraindicated
- Isocarboxazid + Maprotiline Contraindicated
- Maprotiline + Methylene blue Contraindicated
Other interactions of Nilotinib
- Amiodarone + Nilotinib Contraindicated
- Arsenic trioxide + Nilotinib Contraindicated
- Disopyramide + Nilotinib Contraindicated
- Dofetilide + Nilotinib Contraindicated
- Dronedarone + Nilotinib Contraindicated
- Droperidol + Nilotinib Contraindicated
Frequently asked questions
Can I take Maprotiline with Nilotinib?
MediHelp rates the interaction as major. Maprotiline and Nilotinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs can prolong the QT interval, and nilotinib carries a boxed warning for QT prolongation and sudden death. Giving them together increases the risk of torsades de pointes and ventricular arrhythmia.
How serious is the interaction between Maprotiline and Nilotinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible and choose a non-QT-prolonging antidepressant. If unavoidable, obtain a baseline ECG, correct potassium and magnesium, and monitor the QTc regularly.
What other medicines interact with Maprotiline?
MediHelp also lists interactions of Maprotiline with, for example, Arsenic trioxide, Disopyramide, Dofetilide. The full list is on the Maprotiline page.
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