Drug interactions
Maprotiline + Ofloxacin
Severity: Moderate
Maprotiline and Ofloxacin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents can prolong the QT interval, so combined use raises the risk of torsades de pointes. Maprotiline also lowers the seizure threshold, as can fluoroquinolones, adding to neurological risk.
What this interaction means in plain words
Maprotiline and Ofloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Maprotiline belongs to Central Nervous System; Ofloxacin belongs to Anti Bacterial.
Why it happens
Additive QT prolongation through cardiac potassium channel blockade, with additive seizure-threshold lowering.
What to do
Obtain baseline ECG, correct electrolytes and monitor QTc. Prefer an alternative antibiotic in patients with seizure history or other risk factors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ofloxacin
- Ofloxacin + Thioridazine Contraindicated
- Adagrasib + Ofloxacin Major
- Amiodarone + Ofloxacin Major
- Amisulpride + Ofloxacin Major
- Anagrelide + Ofloxacin Major
- Arsenic trioxide + Ofloxacin Major
Other interactions of Maprotiline
- Arsenic trioxide + Maprotiline Contraindicated
- Disopyramide + Maprotiline Contraindicated
- Dofetilide + Maprotiline Contraindicated
- Ibutilide + Maprotiline Contraindicated
- Isocarboxazid + Maprotiline Contraindicated
- Maprotiline + Methylene blue Contraindicated
Frequently asked questions
Can I take Maprotiline with Ofloxacin?
MediHelp rates the interaction as moderate. Maprotiline and Ofloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents can prolong the QT interval, so combined use raises the risk of torsades de pointes. Maprotiline also lowers the seizure threshold, as can fluoroquinolones, adding to neurological risk.
How serious is the interaction between Maprotiline and Ofloxacin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain baseline ECG, correct electrolytes and monitor QTc. Prefer an alternative antibiotic in patients with seizure history or other risk factors.
What other medicines interact with Ofloxacin?
MediHelp also lists interactions of Ofloxacin with, for example, Thioridazine, Adagrasib, Amiodarone. The full list is on the Ofloxacin page.
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