Drug interactions
Maprotiline + Oxazepam
Severity: Moderate
Maprotiline and Oxazepam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs depress the central nervous system, so together they can cause marked drowsiness, impaired coordination and slowed thinking. Maprotiline can also lower the seizure threshold, and sedation raises the risk of falls and accidents.
What this interaction means in plain words
Maprotiline and Oxazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Maprotiline belongs to Central Nervous System; Oxazepam belongs to Central Nervous System.
Why it happens
Additive CNS depression from GABA-A enhancement by oxazepam and antihistaminic and anticholinergic effects of maprotiline.
What to do
Use the lowest effective doses and monitor for excess sedation and psychomotor impairment, especially at initiation and in older patients. Advise against driving and alcohol.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Oxazepam
- Calcium / magnesium / potassium / sodium oxybates + Oxazepam Contraindicated
- Oxazepam + Sodium oxybate Contraindicated
- Alfentanil + Oxazepam Major
- Amobarbital + Oxazepam Major
- Baclofen + Oxazepam Major
- Belladonna and opium + Oxazepam Major
Other interactions of Maprotiline
- Arsenic trioxide + Maprotiline Contraindicated
- Disopyramide + Maprotiline Contraindicated
- Dofetilide + Maprotiline Contraindicated
- Ibutilide + Maprotiline Contraindicated
- Isocarboxazid + Maprotiline Contraindicated
- Maprotiline + Methylene blue Contraindicated
Frequently asked questions
Can I take Maprotiline with Oxazepam?
MediHelp rates the interaction as moderate. Maprotiline and Oxazepam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs depress the central nervous system, so together they can cause marked drowsiness, impaired coordination and slowed thinking. Maprotiline can also lower the seizure threshold, and sedation raises the risk of falls and accidents.
How serious is the interaction between Maprotiline and Oxazepam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and monitor for excess sedation and psychomotor impairment, especially at initiation and in older patients. Advise against driving and alcohol.
What other medicines interact with Oxazepam?
MediHelp also lists interactions of Oxazepam with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Alfentanil. The full list is on the Oxazepam page.
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