Drug interactions
Maprotiline + Oxybutynin
Severity: Moderate
Maprotiline and Oxybutynin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Maprotiline is a tetracyclic antidepressant with anticholinergic activity. Combined with oxybutynin it can add to dry mouth, constipation, urinary retention, tachycardia and confusion.
What this interaction means in plain words
Maprotiline and Oxybutynin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Maprotiline belongs to Central Nervous System; Oxybutynin belongs to Genitourinary.
Why it happens
Additive antimuscarinic effects.
What to do
Monitor for anticholinergic toxicity, especially in the elderly, and use the lowest effective doses.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Oxybutynin
Other interactions of Maprotiline
- Arsenic trioxide + Maprotiline Contraindicated
- Disopyramide + Maprotiline Contraindicated
- Dofetilide + Maprotiline Contraindicated
- Ibutilide + Maprotiline Contraindicated
- Isocarboxazid + Maprotiline Contraindicated
- Maprotiline + Methylene blue Contraindicated
Frequently asked questions
Can I take Maprotiline with Oxybutynin?
MediHelp rates the interaction as moderate. Maprotiline and Oxybutynin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Maprotiline is a tetracyclic antidepressant with anticholinergic activity. Combined with oxybutynin it can add to dry mouth, constipation, urinary retention, tachycardia and confusion.
How serious is the interaction between Maprotiline and Oxybutynin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic toxicity, especially in the elderly, and use the lowest effective doses.
What other medicines interact with Oxybutynin?
MediHelp also lists interactions of Oxybutynin with, for example, Bethanechol, Clozapine, Potassium chloride. The full list is on the Oxybutynin page.
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