Drug interactions
Maprotiline + Pazopanib
Severity: Major
Maprotiline and Pazopanib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs are associated with QT prolongation, so combined use may raise the risk of ventricular arrhythmias including torsades de pointes. The risk is higher with electrolyte disturbances, heart disease or other QT-prolonging drugs.
What this interaction means in plain words
Maprotiline and Pazopanib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Maprotiline belongs to Central Nervous System; Pazopanib belongs to Oncology.
Why it happens
Additive QT interval prolongation.
What to do
Check baseline and periodic ECGs and correct potassium and magnesium before and during treatment. Prefer an antidepressant with less QT effect if feasible.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Maprotiline
- Arsenic trioxide + Maprotiline Contraindicated
- Disopyramide + Maprotiline Contraindicated
- Dofetilide + Maprotiline Contraindicated
- Ibutilide + Maprotiline Contraindicated
- Isocarboxazid + Maprotiline Contraindicated
- Maprotiline + Methylene blue Contraindicated
Other interactions of Pazopanib
- Adagrasib + Pazopanib Major
- Amiodarone + Pazopanib Major
- Amisulpride + Pazopanib Major
- Amobarbital + Pazopanib Major
- Anagrelide + Pazopanib Major
- Apalutamide + Pazopanib Major
Frequently asked questions
Can I take Maprotiline with Pazopanib?
MediHelp rates the interaction as major. Maprotiline and Pazopanib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs are associated with QT prolongation, so combined use may raise the risk of ventricular arrhythmias including torsades de pointes. The risk is higher with electrolyte disturbances, heart disease or other QT-prolonging drugs.
How serious is the interaction between Maprotiline and Pazopanib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check baseline and periodic ECGs and correct potassium and magnesium before and during treatment. Prefer an antidepressant with less QT effect if feasible.
What other medicines interact with Maprotiline?
MediHelp also lists interactions of Maprotiline with, for example, Arsenic trioxide, Disopyramide, Dofetilide. The full list is on the Maprotiline page.
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