Drug interactions
Maprotiline + Pseudoephedrine
Severity: Moderate
Maprotiline and Pseudoephedrine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Maprotiline inhibits norepinephrine reuptake and may alter the effects of pseudoephedrine. Patients may have raised blood pressure, tachycardia or arrhythmias, or a variable response.
What this interaction means in plain words
Maprotiline and Pseudoephedrine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Maprotiline belongs to Central Nervous System; Pseudoephedrine belongs to Respiratory.
Why it happens
Inhibition of norepinephrine reuptake and neuronal uptake of indirect sympathomimetics alters adrenergic pressor responses.
What to do
Prefer non-sympathomimetic decongestants. If pseudoephedrine is used, monitor blood pressure and heart rate.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Pseudoephedrine
- Isocarboxazid + Pseudoephedrine Contraindicated
- Phenelzine + Pseudoephedrine Contraindicated
- Pseudoephedrine + Rasagiline Contraindicated
- Pseudoephedrine + Selegiline Contraindicated
- Pseudoephedrine + Selegiline transdermal Contraindicated
- Pseudoephedrine + Tranylcypromine Contraindicated
Other interactions of Maprotiline
- Arsenic trioxide + Maprotiline Contraindicated
- Disopyramide + Maprotiline Contraindicated
- Dofetilide + Maprotiline Contraindicated
- Ibutilide + Maprotiline Contraindicated
- Isocarboxazid + Maprotiline Contraindicated
- Maprotiline + Methylene blue Contraindicated
Frequently asked questions
Can I take Maprotiline with Pseudoephedrine?
MediHelp rates the interaction as moderate. Maprotiline and Pseudoephedrine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Maprotiline inhibits norepinephrine reuptake and may alter the effects of pseudoephedrine. Patients may have raised blood pressure, tachycardia or arrhythmias, or a variable response.
How serious is the interaction between Maprotiline and Pseudoephedrine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer non-sympathomimetic decongestants. If pseudoephedrine is used, monitor blood pressure and heart rate.
What other medicines interact with Pseudoephedrine?
MediHelp also lists interactions of Pseudoephedrine with, for example, Isocarboxazid, Phenelzine, Rasagiline. The full list is on the Pseudoephedrine page.
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