Drug interactions
Maprotiline + Rifabutin
Severity: Moderate
Maprotiline and Rifabutin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rifabutin is an enzyme inducer and may lower maprotiline concentrations, reducing antidepressant effect. The induction by rifabutin is weaker than that by rifampicin, so the effect is likely modest.
What this interaction means in plain words
Maprotiline and Rifabutin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Maprotiline belongs to Central Nervous System; Rifabutin belongs to Anti Bacterial.
Why it happens
Induction of hepatic CYP enzymes by rifabutin increases maprotiline metabolism.
What to do
Monitor for loss of antidepressant response and adjust the maprotiline dose if needed. Reassess the dose when rifabutin is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Maprotiline
- Arsenic trioxide + Maprotiline Contraindicated
- Disopyramide + Maprotiline Contraindicated
- Dofetilide + Maprotiline Contraindicated
- Ibutilide + Maprotiline Contraindicated
- Isocarboxazid + Maprotiline Contraindicated
- Maprotiline + Methylene blue Contraindicated
Other interactions of Rifabutin
- Cabotegravir + Rifabutin Contraindicated
- Lorlatinib + Rifabutin Contraindicated
- Rifabutin + Voriconazole Contraindicated
- Apixaban + Rifabutin Major
- Axitinib + Rifabutin Major
- Brexpiprazole + Rifabutin Major
Frequently asked questions
Can I take Maprotiline with Rifabutin?
MediHelp rates the interaction as moderate. Maprotiline and Rifabutin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Rifabutin is an enzyme inducer and may lower maprotiline concentrations, reducing antidepressant effect. The induction by rifabutin is weaker than that by rifampicin, so the effect is likely modest.
How serious is the interaction between Maprotiline and Rifabutin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for loss of antidepressant response and adjust the maprotiline dose if needed. Reassess the dose when rifabutin is stopped.
What other medicines interact with Maprotiline?
MediHelp also lists interactions of Maprotiline with, for example, Arsenic trioxide, Disopyramide, Dofetilide. The full list is on the Maprotiline page.
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