Drug interactions
Maprotiline + Selegiline
Severity: Contraindicated
Maprotiline and Selegiline: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Selegiline is an MAO-B inhibitor that becomes nonselective at higher doses and is labeled to be avoided with tricyclic and related antidepressants. Combined use has caused serotonin syndrome and severe blood pressure changes.
What this interaction means in plain words
Maprotiline and Selegiline are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Maprotiline belongs to Central Nervous System; Selegiline belongs to Central Nervous System.
Why it happens
MAO inhibition plus inhibition of noradrenaline reuptake increases synaptic monoamines, which can cause serotonin toxicity and hypertensive reactions.
What to do
Do not co-administer, and observe the washout period required in labeling when switching between the agents. If exposure occurs, stop both drugs and treat serotonin toxicity supportively.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Maprotiline
- Arsenic trioxide + Maprotiline Contraindicated
- Disopyramide + Maprotiline Contraindicated
- Dofetilide + Maprotiline Contraindicated
- Ibutilide + Maprotiline Contraindicated
- Isocarboxazid + Maprotiline Contraindicated
- Maprotiline + Methylene blue Contraindicated
Other interactions of Selegiline
- Amitriptyline + Selegiline Contraindicated
- Amoxapine + Selegiline Contraindicated
- Atomoxetine + Selegiline Contraindicated
- Benzphetamine + Selegiline Contraindicated
- Brimonidine + Selegiline Contraindicated
- Buprenorphine long-acting + Selegiline Contraindicated
Frequently asked questions
Can I take Maprotiline with Selegiline?
MediHelp rates the interaction as contraindicated. Maprotiline and Selegiline are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Selegiline is an MAO-B inhibitor that becomes nonselective at higher doses and is labeled to be avoided with tricyclic and related antidepressants. Combined use has caused serotonin syndrome and severe blood pressure changes.
How serious is the interaction between Maprotiline and Selegiline?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not co-administer, and observe the washout period required in labeling when switching between the agents. If exposure occurs, stop both drugs and treat serotonin toxicity supportively.
What other medicines interact with Maprotiline?
MediHelp also lists interactions of Maprotiline with, for example, Arsenic trioxide, Disopyramide, Dofetilide. The full list is on the Maprotiline page.
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