Drug interactions
Maprotiline + Selpercatinib
Severity: Moderate
Maprotiline and Selpercatinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can prolong the QT interval. Their combined use may raise the risk of torsades de pointes, particularly with electrolyte abnormalities or cardiac disease.
What this interaction means in plain words
Maprotiline and Selpercatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Maprotiline belongs to Central Nervous System; Selpercatinib belongs to Oncology.
Why it happens
Additive QT prolongation through effects on cardiac repolarization.
What to do
Monitor ECG and electrolytes at baseline and periodically, correcting potassium and magnesium. Consider an alternative antidepressant or selpercatinib dose reduction if QTc becomes markedly prolonged.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Maprotiline and Selpercatinib, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Maprotiline
- Arsenic trioxide + Maprotiline Contraindicated
- Disopyramide + Maprotiline Contraindicated
- Dofetilide + Maprotiline Contraindicated
- Ibutilide + Maprotiline Contraindicated
- Isocarboxazid + Maprotiline Contraindicated
- Maprotiline + Methylene blue Contraindicated
Other interactions of Selpercatinib
Frequently asked questions
Can I take Maprotiline with Selpercatinib?
MediHelp rates the interaction as moderate. Maprotiline and Selpercatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can prolong the QT interval. Their combined use may raise the risk of torsades de pointes, particularly with electrolyte abnormalities or cardiac disease.
How serious is the interaction between Maprotiline and Selpercatinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and electrolytes at baseline and periodically, correcting potassium and magnesium. Consider an alternative antidepressant or selpercatinib dose reduction if QTc becomes markedly prolonged.
What other medicines interact with Maprotiline?
MediHelp also lists interactions of Maprotiline with, for example, Arsenic trioxide, Disopyramide, Dofetilide. The full list is on the Maprotiline page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
