Drug interactions
Maprotiline + Siponimod
Severity: Moderate
Maprotiline and Siponimod: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Siponimod can cause bradycardia and AV conduction delay after initiation, and QT-prolonging drugs such as maprotiline add to arrhythmic risk. Labeling advises caution with drugs that prolong QT or slow heart rate.
What this interaction means in plain words
Maprotiline and Siponimod can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Maprotiline belongs to Central Nervous System; Siponimod belongs to Central Nervous System.
Why it happens
Additive effects of S1P-receptor-mediated bradycardia and drug-induced QT prolongation.
What to do
Obtain an ECG before starting siponimod and consider cardiology advice and extended first-dose monitoring. Monitor heart rate and QTc and correct electrolytes.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Maprotiline
- Arsenic trioxide + Maprotiline Contraindicated
- Disopyramide + Maprotiline Contraindicated
- Dofetilide + Maprotiline Contraindicated
- Ibutilide + Maprotiline Contraindicated
- Isocarboxazid + Maprotiline Contraindicated
- Maprotiline + Methylene blue Contraindicated
Other interactions of Siponimod
- Cladribine + Siponimod Contraindicated
- Fingolimod + Siponimod Contraindicated
- Fluconazole + Siponimod Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Siponimod Contraindicated
- Ponesimod + Siponimod Contraindicated
- Siponimod + Thioridazine Contraindicated
Frequently asked questions
Can I take Maprotiline with Siponimod?
MediHelp rates the interaction as moderate. Maprotiline and Siponimod can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Siponimod can cause bradycardia and AV conduction delay after initiation, and QT-prolonging drugs such as maprotiline add to arrhythmic risk. Labeling advises caution with drugs that prolong QT or slow heart rate.
How serious is the interaction between Maprotiline and Siponimod?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain an ECG before starting siponimod and consider cardiology advice and extended first-dose monitoring. Monitor heart rate and QTc and correct electrolytes.
What other medicines interact with Maprotiline?
MediHelp also lists interactions of Maprotiline with, for example, Arsenic trioxide, Disopyramide, Dofetilide. The full list is on the Maprotiline page.
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