Drug interactions
Maprotiline + Sorafenib
Severity: Major
Maprotiline and Sorafenib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs may prolong the QT interval, so combined use may raise the risk of serious ventricular arrhythmia. Risk is greater with electrolyte abnormalities or underlying cardiac disease.
What this interaction means in plain words
Maprotiline and Sorafenib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Maprotiline belongs to Central Nervous System; Sorafenib belongs to Oncology.
Why it happens
Additive QT interval prolongation.
What to do
Monitor ECG and correct potassium and magnesium before and during therapy. Consider an alternative antidepressant if QTc prolongs.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Maprotiline
- Arsenic trioxide + Maprotiline Contraindicated
- Disopyramide + Maprotiline Contraindicated
- Dofetilide + Maprotiline Contraindicated
- Ibutilide + Maprotiline Contraindicated
- Isocarboxazid + Maprotiline Contraindicated
- Maprotiline + Methylene blue Contraindicated
Other interactions of Sorafenib
Frequently asked questions
Can I take Maprotiline with Sorafenib?
MediHelp rates the interaction as major. Maprotiline and Sorafenib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs may prolong the QT interval, so combined use may raise the risk of serious ventricular arrhythmia. Risk is greater with electrolyte abnormalities or underlying cardiac disease.
How serious is the interaction between Maprotiline and Sorafenib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and correct potassium and magnesium before and during therapy. Consider an alternative antidepressant if QTc prolongs.
What other medicines interact with Maprotiline?
MediHelp also lists interactions of Maprotiline with, for example, Arsenic trioxide, Disopyramide, Dofetilide. The full list is on the Maprotiline page.
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