Drug interactions
Maprotiline + Zuranolone
Severity: Major
Maprotiline and Zuranolone: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs depress the central nervous system. Taken together they may increase sedation, dizziness and impairment of psychomotor performance, including driving ability. The risk is greatest at the start of treatment or after a dose increase.
What this interaction means in plain words
Maprotiline and Zuranolone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Maprotiline belongs to Central Nervous System; Zuranolone belongs to Central Nervous System.
Why it happens
Additive CNS depression: zuranolone is a positive GABA-A receptor modulator and maprotiline is a sedating antidepressant.
What to do
Consider lowering the zuranolone dose if co-use is necessary, and monitor for excess sedation. Advise patients not to drive or operate machinery until the combined effect is known.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Maprotiline
- Arsenic trioxide + Maprotiline Contraindicated
- Disopyramide + Maprotiline Contraindicated
- Dofetilide + Maprotiline Contraindicated
- Ibutilide + Maprotiline Contraindicated
- Isocarboxazid + Maprotiline Contraindicated
- Maprotiline + Methylene blue Contraindicated
Other interactions of Zuranolone
- Alprazolam + Zuranolone Major
- Amobarbital + Zuranolone Major
- Apalutamide + Zuranolone Major
- Asenapine + Zuranolone Major
- Brexpiprazole + Zuranolone Major
- Butorphanol + Zuranolone Major
Frequently asked questions
Can I take Maprotiline with Zuranolone?
MediHelp rates the interaction as major. Maprotiline and Zuranolone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs depress the central nervous system. Taken together they may increase sedation, dizziness and impairment of psychomotor performance, including driving ability. The risk is greatest at the start of treatment or after a dose increase.
How serious is the interaction between Maprotiline and Zuranolone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider lowering the zuranolone dose if co-use is necessary, and monitor for excess sedation. Advise patients not to drive or operate machinery until the combined effect is known.
What other medicines interact with Maprotiline?
MediHelp also lists interactions of Maprotiline with, for example, Arsenic trioxide, Disopyramide, Dofetilide. The full list is on the Maprotiline page.
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