Drug interactions
Marijuana + Meperidine
Severity: Moderate
Marijuana and Meperidine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cannabis can intensify opioid-induced sedation, dizziness and impaired psychomotor performance. Respiratory depression risk may rise with higher doses.
What this interaction means in plain words
Marijuana and Meperidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression through cannabinoid and opioid receptor effects.
What to do
Counsel patients to avoid driving and hazardous tasks and monitor for excessive sedation. Use lower opioid doses if sedation develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Meperidine
- Alvimopan + Meperidine Contraindicated
- Isocarboxazid + Meperidine Contraindicated
- Meperidine + Methylene blue Contraindicated
- Meperidine + Olanzapine / samidorphan Contraindicated
- Meperidine + Phenelzine Contraindicated
- Meperidine + Procarbazine Contraindicated
Frequently asked questions
Can I take Marijuana with Meperidine?
MediHelp rates the interaction as moderate. Marijuana and Meperidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cannabis can intensify opioid-induced sedation, dizziness and impaired psychomotor performance. Respiratory depression risk may rise with higher doses.
How serious is the interaction between Marijuana and Meperidine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel patients to avoid driving and hazardous tasks and monitor for excessive sedation. Use lower opioid doses if sedation develops.
What other medicines interact with Meperidine?
MediHelp also lists interactions of Meperidine with, for example, Alvimopan, Isocarboxazid, Methylene blue. The full list is on the Meperidine page.
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