Drug interactions
Marijuana + Metoprolol
Severity: Minor
Marijuana and Metoprolol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cannabis can increase heart rate and cause postural hypotension, and it may alter the cardiovascular response to metoprolol. Cannabinoids inhibit CYP2D6 in vitro, but clinical evidence of a relevant effect on metoprolol levels is lacking.
What this interaction means in plain words
Marijuana and Metoprolol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible weak CYP2D6 inhibition by cannabinoids plus opposing cardiovascular effects.
What to do
Counsel the patient about dizziness and palpitations. Monitor heart rate and blood pressure in regular users.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Metoprolol
- Metoprolol + Thioridazine Contraindicated
- Amifostine + Metoprolol Major
- Amiodarone + Metoprolol Major
- Atenolol-chlorthalidone + Metoprolol Major
- Atenolol + Metoprolol Major
- Betaxolol + Metoprolol Major
Frequently asked questions
Can I take Marijuana with Metoprolol?
MediHelp rates the interaction as minor. Marijuana and Metoprolol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Cannabis can increase heart rate and cause postural hypotension, and it may alter the cardiovascular response to metoprolol. Cannabinoids inhibit CYP2D6 in vitro, but clinical evidence of a relevant effect on metoprolol levels is lacking.
How serious is the interaction between Marijuana and Metoprolol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel the patient about dizziness and palpitations. Monitor heart rate and blood pressure in regular users.
What other medicines interact with Metoprolol?
MediHelp also lists interactions of Metoprolol with, for example, Thioridazine, Amifostine, Amiodarone. The full list is on the Metoprolol page.
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