Drug interactions
Marijuana + Midazolam
Severity: Moderate
Marijuana and Midazolam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cannabis causes sedation and psychomotor impairment that add to the effects of midazolam. Cannabidiol-containing products may also inhibit CYP3A4 and raise midazolam levels, although the effect is variable.
What this interaction means in plain words
Marijuana and Midazolam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression, plus possible CYP3A4 inhibition by cannabinoids.
What to do
Ask about cannabis use before sedation and reduce the starting midazolam dose with careful titration. Monitor sedation and respiration.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Midazolam
- Atazanavir + Midazolam Contraindicated
- Cobicistat + Midazolam Contraindicated
- Darunavir + Midazolam Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Midazolam Contraindicated
- Fosamprenavir + Midazolam Contraindicated
- Indinavir + Midazolam Contraindicated
Frequently asked questions
Can I take Marijuana with Midazolam?
MediHelp rates the interaction as moderate. Marijuana and Midazolam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cannabis causes sedation and psychomotor impairment that add to the effects of midazolam. Cannabidiol-containing products may also inhibit CYP3A4 and raise midazolam levels, although the effect is variable.
How serious is the interaction between Marijuana and Midazolam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Ask about cannabis use before sedation and reduce the starting midazolam dose with careful titration. Monitor sedation and respiration.
What other medicines interact with Midazolam?
MediHelp also lists interactions of Midazolam with, for example, Atazanavir, Cobicistat, Darunavir. The full list is on the Midazolam page.
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