Drug interactions
Marijuana + Ribociclib
Severity: Minor
Marijuana and Ribociclib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
THC and CBD are metabolized in part by CYP3A4 and CYP2C9, so ribociclib may modestly raise cannabinoid levels and enhance sedation, dizziness or tachycardia. The effect is poorly characterized.
What this interaction means in plain words
Marijuana and Ribociclib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible inhibition of CYP3A4-mediated cannabinoid metabolism by ribociclib.
What to do
Advise patients to start with low cannabis doses and monitor for excess sedation, dizziness and heart rate changes.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ribociclib
- Amiodarone + Ribociclib Contraindicated
- Cisapride + Ribociclib Contraindicated
- Dofetilide + Ribociclib Contraindicated
- Dronedarone + Ribociclib Contraindicated
- Flibanserin + Ribociclib Contraindicated
- Ibutilide + Ribociclib Contraindicated
Frequently asked questions
Can I take Marijuana with Ribociclib?
MediHelp rates the interaction as minor. Marijuana and Ribociclib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. THC and CBD are metabolized in part by CYP3A4 and CYP2C9, so ribociclib may modestly raise cannabinoid levels and enhance sedation, dizziness or tachycardia. The effect is poorly characterized.
How serious is the interaction between Marijuana and Ribociclib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise patients to start with low cannabis doses and monitor for excess sedation, dizziness and heart rate changes.
What other medicines interact with Ribociclib?
MediHelp also lists interactions of Ribociclib with, for example, Amiodarone, Cisapride, Dofetilide. The full list is on the Ribociclib page.
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