Drug interactions
Marijuana + Sirolimus
Severity: Moderate
Marijuana and Sirolimus: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cannabinoids such as cannabidiol may inhibit CYP3A4 and raise sirolimus levels, though data are limited and inconsistent. Increased exposure could cause toxicity.
What this interaction means in plain words
Marijuana and Sirolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Cannabidiol may inhibit CYP3A4 and reduce sirolimus metabolism.
What to do
Advise against cannabis use where possible; if used, monitor sirolimus trough levels and for adverse effects.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sirolimus
- Adenovirus types 4 and 7 live + Sirolimus Contraindicated
- Bcg vaccine live + Sirolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Sirolimus Contraindicated
- Ketoconazole + Sirolimus Contraindicated
- Levoketoconazole + Sirolimus Contraindicated
- Measles mumps and rubella vaccine live + Sirolimus Contraindicated
Frequently asked questions
Can I take Marijuana with Sirolimus?
MediHelp rates the interaction as moderate. Marijuana and Sirolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cannabinoids such as cannabidiol may inhibit CYP3A4 and raise sirolimus levels, though data are limited and inconsistent. Increased exposure could cause toxicity.
How serious is the interaction between Marijuana and Sirolimus?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise against cannabis use where possible; if used, monitor sirolimus trough levels and for adverse effects.
What other medicines interact with Sirolimus?
MediHelp also lists interactions of Sirolimus with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Sirolimus page.
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