Drug interactions
Marijuana + Voriconazole
Severity: Minor
Marijuana and Voriconazole: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Voriconazole may increase exposure to cannabinoids such as THC and CBD, which are partly metabolized by CYP3A4 and CYP2C. This can enhance sedation, dizziness, tachycardia and impaired psychomotor performance.
What this interaction means in plain words
Marijuana and Voriconazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Inhibition of CYP3A4 (and CYP2C19) by voriconazole reduces cannabinoid clearance.
What to do
Counsel the patient about possible increased sedation and impairment, and avoid driving. Lower the cannabinoid dose if adverse effects occur.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Voriconazole
- Avanafil + Voriconazole Contraindicated
- Butabarbital + Voriconazole Contraindicated
- Carbamazepine + Voriconazole Contraindicated
- Conivaptan + Voriconazole Contraindicated
- Dihydroergotamine intranasal + Voriconazole Contraindicated
- Dihydroergotamine + Voriconazole Contraindicated
Frequently asked questions
Can I take Marijuana with Voriconazole?
MediHelp rates the interaction as minor. Marijuana and Voriconazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Voriconazole may increase exposure to cannabinoids such as THC and CBD, which are partly metabolized by CYP3A4 and CYP2C. This can enhance sedation, dizziness, tachycardia and impaired psychomotor performance.
How serious is the interaction between Marijuana and Voriconazole?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel the patient about possible increased sedation and impairment, and avoid driving. Lower the cannabinoid dose if adverse effects occur.
What other medicines interact with Voriconazole?
MediHelp also lists interactions of Voriconazole with, for example, Avanafil, Butabarbital, Carbamazepine. The full list is on the Voriconazole page.
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