Drug interactions
Mavacamten + Mifepristone
Severity: Major
Mavacamten and Mifepristone: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mavacamten is cleared mainly by CYP2C19 with CYP3A4 contributing. Mifepristone inhibits CYP3A4 and may raise mavacamten exposure, increasing the risk of excessive reduction in ejection fraction and heart failure.
What this interaction means in plain words
Mavacamten and Mifepristone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Mavacamten belongs to Cardiovascular; Mifepristone belongs to Endocrine.
Why it happens
Mifepristone inhibits CYP3A4 metabolism of mavacamten, increasing its systemic exposure.
What to do
Avoid the combination where possible. If mifepristone is required, monitor LVEF and clinical heart failure signs closely and adjust the mavacamten dose per labeling.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Mifepristone
- Apixaban + Mifepristone Contraindicated
- Argatroban + Mifepristone Contraindicated
- Cisapride + Mifepristone Contraindicated
- Cortisone + Mifepristone Contraindicated
- Cyclosporin + Mifepristone Contraindicated
- Dabigatran etexilate + Mifepristone Contraindicated
Other interactions of Mavacamten
- Apalutamide + Mavacamten Contraindicated
- Carbamazepine + Mavacamten Contraindicated
- Clarithromycin + Mavacamten Contraindicated
- Dexlansoprazole + Mavacamten Contraindicated
- Efavirenz + Mavacamten Contraindicated
- Enzalutamide + Mavacamten Contraindicated
Frequently asked questions
Can I take Mavacamten with Mifepristone?
MediHelp rates the interaction as major. Mavacamten and Mifepristone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Mavacamten is cleared mainly by CYP2C19 with CYP3A4 contributing. Mifepristone inhibits CYP3A4 and may raise mavacamten exposure, increasing the risk of excessive reduction in ejection fraction and heart failure.
How serious is the interaction between Mavacamten and Mifepristone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible. If mifepristone is required, monitor LVEF and clinical heart failure signs closely and adjust the mavacamten dose per labeling.
What other medicines interact with Mifepristone?
MediHelp also lists interactions of Mifepristone with, for example, Apixaban, Argatroban, Cisapride. The full list is on the Mifepristone page.
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