Drug interactions
Mavacamten + Nadolol
Severity: Moderate
Mavacamten and Nadolol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mavacamten reduces cardiac contractility, and beta-blockers have negative inotropic effects, so heart failure from reduced ejection fraction may occur. Beta-blockers are often used alongside mavacamten in obstructive hypertrophic cardiomyopathy under monitoring.
What this interaction means in plain words
Mavacamten and Nadolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Mavacamten belongs to Cardiovascular; Nadolol belongs to Cardiovascular.
Why it happens
Additive negative inotropic effects.
What to do
Monitor left ventricular ejection fraction and symptoms of heart failure, and adjust mavacamten dose per echocardiographic guidance. Interrupt mavacamten if systolic dysfunction develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nadolol
- Acebutolol + Nadolol Major
- Adrenaline-articaine + Nadolol Major
- Albuterol + Nadolol Major
- Amifostine + Nadolol Major
- Amiodarone + Nadolol Major
- Arformoterol + Nadolol Major
Other interactions of Mavacamten
- Apalutamide + Mavacamten Contraindicated
- Carbamazepine + Mavacamten Contraindicated
- Clarithromycin + Mavacamten Contraindicated
- Dexlansoprazole + Mavacamten Contraindicated
- Efavirenz + Mavacamten Contraindicated
- Enzalutamide + Mavacamten Contraindicated
Frequently asked questions
Can I take Mavacamten with Nadolol?
MediHelp rates the interaction as moderate. Mavacamten and Nadolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Mavacamten reduces cardiac contractility, and beta-blockers have negative inotropic effects, so heart failure from reduced ejection fraction may occur. Beta-blockers are often used alongside mavacamten in obstructive hypertrophic cardiomyopathy under monitoring.
How serious is the interaction between Mavacamten and Nadolol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor left ventricular ejection fraction and symptoms of heart failure, and adjust mavacamten dose per echocardiographic guidance. Interrupt mavacamten if systolic dysfunction develops.
What other medicines interact with Nadolol?
MediHelp also lists interactions of Nadolol with, for example, Acebutolol, Adrenaline-articaine, Albuterol. The full list is on the Nadolol page.
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