Drug interactions
Mavacamten + Nebivolol
Severity: Major
Mavacamten and Nebivolol: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mavacamten reduces cardiac contractility and nebivolol adds negative chronotropic and inotropic effects. Combined use can contribute to systolic dysfunction and heart failure, though beta-blockers are often used together in hypertrophic cardiomyopathy under supervision.
What this interaction means in plain words
Mavacamten and Nebivolol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Mavacamten belongs to Cardiovascular; Nebivolol belongs to Cardiovascular.
Why it happens
Additive negative inotropic effects via myosin inhibition and beta-adrenergic blockade.
What to do
Monitor LVEF with echocardiography per mavacamten labeling and watch for heart failure symptoms. Interrupt mavacamten if systolic function declines.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Nebivolol
- Acebutolol + Nebivolol Major
- Aldesleukin + Nebivolol Major
- Amiodarone + Nebivolol Major
- Atenolol-chlorthalidone + Nebivolol Major
- Atenolol + Nebivolol Major
- Betaxolol + Nebivolol Major
Other interactions of Mavacamten
- Apalutamide + Mavacamten Contraindicated
- Carbamazepine + Mavacamten Contraindicated
- Clarithromycin + Mavacamten Contraindicated
- Dexlansoprazole + Mavacamten Contraindicated
- Efavirenz + Mavacamten Contraindicated
- Enzalutamide + Mavacamten Contraindicated
Frequently asked questions
Can I take Mavacamten with Nebivolol?
MediHelp rates the interaction as major. Mavacamten and Nebivolol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Mavacamten reduces cardiac contractility and nebivolol adds negative chronotropic and inotropic effects. Combined use can contribute to systolic dysfunction and heart failure, though beta-blockers are often used together in hypertrophic cardiomyopathy under supervision.
How serious is the interaction between Mavacamten and Nebivolol?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor LVEF with echocardiography per mavacamten labeling and watch for heart failure symptoms. Interrupt mavacamten if systolic function declines.
What other medicines interact with Nebivolol?
MediHelp also lists interactions of Nebivolol with, for example, Acebutolol, Aldesleukin, Amiodarone. The full list is on the Nebivolol page.
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