Drug interactions
Mavacamten + Nicardipine
Severity: Major
Mavacamten and Nicardipine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mavacamten is cleared mainly by CYP2C19 with a contribution from CYP3A4, and increased exposure can reduce ejection fraction and cause heart failure. Nicardipine can inhibit CYP2C19 and CYP3A4 in vitro, though the clinical effect is not well characterized.
What this interaction means in plain words
Mavacamten and Nicardipine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Mavacamten belongs to Cardiovascular; Nicardipine belongs to Cardiovascular.
Why it happens
Possible inhibition of CYP2C19 and CYP3A4 metabolism of mavacamten by nicardipine, raising its exposure.
What to do
Monitor left ventricular ejection fraction and heart failure symptoms, and adjust the mavacamten dose per echocardiographic response. Consider an alternative antihypertensive.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Nicardipine
Other interactions of Mavacamten
- Apalutamide + Mavacamten Contraindicated
- Carbamazepine + Mavacamten Contraindicated
- Clarithromycin + Mavacamten Contraindicated
- Dexlansoprazole + Mavacamten Contraindicated
- Efavirenz + Mavacamten Contraindicated
- Enzalutamide + Mavacamten Contraindicated
Frequently asked questions
Can I take Mavacamten with Nicardipine?
MediHelp rates the interaction as major. Mavacamten and Nicardipine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Mavacamten is cleared mainly by CYP2C19 with a contribution from CYP3A4, and increased exposure can reduce ejection fraction and cause heart failure. Nicardipine can inhibit CYP2C19 and CYP3A4 in vitro, though the clinical effect is not well characterized.
How serious is the interaction between Mavacamten and Nicardipine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor left ventricular ejection fraction and heart failure symptoms, and adjust the mavacamten dose per echocardiographic response. Consider an alternative antihypertensive.
What other medicines interact with Nicardipine?
MediHelp also lists interactions of Nicardipine with, for example, Amifostine, Amlodipine-olmesartan-hydrochlorothiazide, Betrixaban. The full list is on the Nicardipine page.
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