Drug interactions
Mavacamten + Sertraline
Severity: Major
Mavacamten and Sertraline: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mavacamten is cleared largely by CYP2C19, which sertraline inhibits modestly. Higher mavacamten exposure may reduce ejection fraction and lead to heart failure from systolic dysfunction.
What this interaction means in plain words
Mavacamten and Sertraline can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Mavacamten belongs to Cardiovascular; Sertraline belongs to Central Nervous System.
Why it happens
Sertraline inhibition of CYP2C19 may reduce mavacamten clearance.
What to do
Monitor LVEF and clinical status closely when starting, stopping or changing the sertraline dose. Adjust mavacamten according to echocardiographic findings per labeling.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Sertraline
- Isocarboxazid + Sertraline Contraindicated
- Methylene blue + Sertraline Contraindicated
- Phenelzine + Sertraline Contraindicated
- Pimozide + Sertraline Contraindicated
- Selegiline transdermal + Sertraline Contraindicated
- Selegiline + Sertraline Contraindicated
Other interactions of Mavacamten
- Apalutamide + Mavacamten Contraindicated
- Carbamazepine + Mavacamten Contraindicated
- Clarithromycin + Mavacamten Contraindicated
- Dexlansoprazole + Mavacamten Contraindicated
- Efavirenz + Mavacamten Contraindicated
- Enzalutamide + Mavacamten Contraindicated
Frequently asked questions
Can I take Mavacamten with Sertraline?
MediHelp rates the interaction as major. Mavacamten and Sertraline can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Mavacamten is cleared largely by CYP2C19, which sertraline inhibits modestly. Higher mavacamten exposure may reduce ejection fraction and lead to heart failure from systolic dysfunction.
How serious is the interaction between Mavacamten and Sertraline?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor LVEF and clinical status closely when starting, stopping or changing the sertraline dose. Adjust mavacamten according to echocardiographic findings per labeling.
What other medicines interact with Sertraline?
MediHelp also lists interactions of Sertraline with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Sertraline page.
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