Drug interactions
Mavacamten + Valproic acid
Severity: Moderate
Mavacamten and Valproic acid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mavacamten is cleared mainly by CYP2C19 and CYP3A4, so inhibitors can raise its levels and reduce ejection fraction. The inhibitory effect of valproate on these enzymes is weak and not well characterized.
What this interaction means in plain words
Mavacamten and Valproic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Mavacamten belongs to Cardiovascular; Valproic acid belongs to Central Nervous System.
Why it happens
Possible inhibition of CYP2C19 metabolism of mavacamten by valproate.
What to do
Monitor LVEF and clinical status per mavacamten labeling when valproate is started or stopped, and adjust the mavacamten dose per echocardiographic findings.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Valproic acid
- Ertapenem + Valproic acid Contraindicated
- Imipenem / cilastatin / relebactam + Valproic acid Contraindicated
- Imipenem / cilastatin + Valproic acid Contraindicated
- Meropenem / vaborbactam + Valproic acid Contraindicated
- Meropenem + Valproic acid Contraindicated
- Calcium / magnesium / potassium / sodium oxybates + Valproic acid Major
Other interactions of Mavacamten
- Apalutamide + Mavacamten Contraindicated
- Carbamazepine + Mavacamten Contraindicated
- Clarithromycin + Mavacamten Contraindicated
- Dexlansoprazole + Mavacamten Contraindicated
- Efavirenz + Mavacamten Contraindicated
- Enzalutamide + Mavacamten Contraindicated
Frequently asked questions
Can I take Mavacamten with Valproic acid?
MediHelp rates the interaction as moderate. Mavacamten and Valproic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Mavacamten is cleared mainly by CYP2C19 and CYP3A4, so inhibitors can raise its levels and reduce ejection fraction. The inhibitory effect of valproate on these enzymes is weak and not well characterized.
How serious is the interaction between Mavacamten and Valproic acid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor LVEF and clinical status per mavacamten labeling when valproate is started or stopped, and adjust the mavacamten dose per echocardiographic findings.
What other medicines interact with Valproic acid?
MediHelp also lists interactions of Valproic acid with, for example, Ertapenem, Imipenem / cilastatin / relebactam, Imipenem / cilastatin. The full list is on the Valproic acid page.
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