Drug interactions
Mavacamten + Verapamil
Severity: Major
Mavacamten and Verapamil: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs reduce cardiac contractility, so combining them may precipitate reduced ejection fraction and heart failure. Verapamil also inhibits CYP3A4 and may raise mavacamten exposure.
What this interaction means in plain words
Mavacamten and Verapamil can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Mavacamten belongs to Cardiovascular; Verapamil belongs to Cardiovascular.
Why it happens
Additive negative inotropic effects, together with CYP3A4 inhibition by verapamil increasing mavacamten levels.
What to do
Monitor LVEF and clinical status closely when starting or changing verapamil or mavacamten, and follow echocardiographic dose-titration guidance. Interrupt mavacamten if heart failure symptoms or reduced LVEF occur.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Verapamil
- Dofetilide + Verapamil Contraindicated
- Flibanserin + Verapamil Contraindicated
- Lomitapide + Verapamil Contraindicated
- Lonafarnib + Verapamil Contraindicated
- Pimozide + Verapamil Contraindicated
- Acebutolol + Verapamil Major
Other interactions of Mavacamten
- Apalutamide + Mavacamten Contraindicated
- Carbamazepine + Mavacamten Contraindicated
- Clarithromycin + Mavacamten Contraindicated
- Dexlansoprazole + Mavacamten Contraindicated
- Efavirenz + Mavacamten Contraindicated
- Enzalutamide + Mavacamten Contraindicated
Frequently asked questions
Can I take Mavacamten with Verapamil?
MediHelp rates the interaction as major. Mavacamten and Verapamil can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs reduce cardiac contractility, so combining them may precipitate reduced ejection fraction and heart failure. Verapamil also inhibits CYP3A4 and may raise mavacamten exposure.
How serious is the interaction between Mavacamten and Verapamil?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor LVEF and clinical status closely when starting or changing verapamil or mavacamten, and follow echocardiographic dose-titration guidance. Interrupt mavacamten if heart failure symptoms or reduced LVEF occur.
What other medicines interact with Verapamil?
MediHelp also lists interactions of Verapamil with, for example, Dofetilide, Flibanserin, Lomitapide. The full list is on the Verapamil page.
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