Drug interactions
Measles mumps and rubella vaccine + Onasemnogene abeparvovec
Severity: Moderate
Measles mumps and rubella vaccine and Onasemnogene abeparvovec: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Onasemnogene is a gene therapy that is not itself broadly immunosuppressive, but it is given with prolonged corticosteroids to blunt liver and immune reactions. Those corticosteroids may reduce the vaccine response and make live vaccines less safe.
What this interaction means in plain words
Measles mumps and rubella vaccine and Onasemnogene abeparvovec can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Measles mumps and rubella vaccine belongs to Miscellaneous; Onasemnogene abeparvovec belongs to Miscellaneous.
Why it happens
Concomitant corticosteroid immunosuppression, not the gene therapy itself, may reduce vaccine response and impair control of live viruses.
What to do
Plan the vaccination schedule around the steroid course and defer live vaccines while the patient is on immunosuppressive steroid doses. Seek specialist advice on timing.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Measles mumps and rubella vaccine
- Adalimumab + Measles mumps and rubella vaccine Contraindicated
- Anakinra + Measles mumps and rubella vaccine Contraindicated
- Antithymocyte globulin equine + Measles mumps and rubella vaccine Contraindicated
- Antithymocyte globulin rabbit + Measles mumps and rubella vaccine Contraindicated
- Azathioprine + Measles mumps and rubella vaccine Contraindicated
- Basiliximab + Measles mumps and rubella vaccine Contraindicated
Other interactions of Onasemnogene abeparvovec
Frequently asked questions
Can I take Measles mumps and rubella vaccine with Onasemnogene abeparvovec?
MediHelp rates the interaction as moderate. Measles mumps and rubella vaccine and Onasemnogene abeparvovec can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Onasemnogene is a gene therapy that is not itself broadly immunosuppressive, but it is given with prolonged corticosteroids to blunt liver and immune reactions. Those corticosteroids may reduce the vaccine response and make live vaccines less safe.
How serious is the interaction between Measles mumps and rubella vaccine and Onasemnogene abeparvovec?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Plan the vaccination schedule around the steroid course and defer live vaccines while the patient is on immunosuppressive steroid doses. Seek specialist advice on timing.
What other medicines interact with Measles mumps and rubella vaccine?
MediHelp also lists interactions of Measles mumps and rubella vaccine with, for example, Adalimumab, Anakinra, Antithymocyte globulin equine. The full list is on the Measles mumps and rubella vaccine page.
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