Drug interactions
Human papillomavirus vaccine + Onasemnogene abeparvovec
Severity: Minor
Human papillomavirus vaccine and Onasemnogene abeparvovec: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Onasemnogene is given with corticosteroid prophylaxis, which may reduce responses to inactivated vaccines. The vaccine itself is not live, so the main concern is reduced immunogenicity.
What this interaction means in plain words
Human papillomavirus vaccine and Onasemnogene abeparvovec have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Human papillomavirus vaccine belongs to Miscellaneous; Onasemnogene abeparvovec belongs to Miscellaneous.
Why it happens
Corticosteroid co-therapy used with the gene therapy causes immunosuppression that may blunt vaccine response.
What to do
Schedule vaccination around the steroid course where feasible, and consider confirming immune response or revaccinating after steroids are completed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Human papillomavirus vaccine
- Antithymocyte globulin equine + Human papillomavirus vaccine Moderate
- Antithymocyte globulin rabbit + Human papillomavirus vaccine Moderate
- Atidarsagene autotemcel + Human papillomavirus vaccine Moderate
- Belimumab + Human papillomavirus vaccine Moderate
- Cortisone + Human papillomavirus vaccine Moderate
- Cyclosporine + Human papillomavirus vaccine Moderate
Other interactions of Onasemnogene abeparvovec
Frequently asked questions
Can I take Human papillomavirus vaccine with Onasemnogene abeparvovec?
MediHelp rates the interaction as minor. Human papillomavirus vaccine and Onasemnogene abeparvovec have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Onasemnogene is given with corticosteroid prophylaxis, which may reduce responses to inactivated vaccines. The vaccine itself is not live, so the main concern is reduced immunogenicity.
How serious is the interaction between Human papillomavirus vaccine and Onasemnogene abeparvovec?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Schedule vaccination around the steroid course where feasible, and consider confirming immune response or revaccinating after steroids are completed.
What other medicines interact with Human papillomavirus vaccine?
MediHelp also lists interactions of Human papillomavirus vaccine with, for example, Antithymocyte globulin equine, Antithymocyte globulin rabbit, Atidarsagene autotemcel. The full list is on the Human papillomavirus vaccine page.
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