Drug interactions
Measles mumps and rubella vaccine + Procarbazine
Severity: Contraindicated
Measles mumps and rubella vaccine and Procarbazine: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Procarbazine is a cytotoxic, immunosuppressive agent that can impair the response to vaccination. Live attenuated measles, mumps and rubella viruses may replicate excessively and cause disseminated infection.
What this interaction means in plain words
Measles mumps and rubella vaccine and Procarbazine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Measles mumps and rubella vaccine belongs to Miscellaneous; Procarbazine belongs to Oncology.
Why it happens
Cytotoxic immunosuppression impairs the immune response and permits replication of live vaccine viruses.
What to do
Avoid MMR during procarbazine therapy. Vaccinate before treatment where possible, or delay until about 3 months after stopping and immune recovery is confirmed.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Measles mumps and rubella vaccine
- Adalimumab + Measles mumps and rubella vaccine Contraindicated
- Anakinra + Measles mumps and rubella vaccine Contraindicated
- Antithymocyte globulin equine + Measles mumps and rubella vaccine Contraindicated
- Antithymocyte globulin rabbit + Measles mumps and rubella vaccine Contraindicated
- Azathioprine + Measles mumps and rubella vaccine Contraindicated
- Basiliximab + Measles mumps and rubella vaccine Contraindicated
Other interactions of Procarbazine
- Adenovirus types 4 and 7 live + Procarbazine Contraindicated
- Amitriptyline + Procarbazine Contraindicated
- Amoxapine + Procarbazine Contraindicated
- Atomoxetine + Procarbazine Contraindicated
- Bcg vaccine live + Procarbazine Contraindicated
- Brimonidine + Procarbazine Contraindicated
Frequently asked questions
Can I take Measles mumps and rubella vaccine with Procarbazine?
MediHelp rates the interaction as contraindicated. Measles mumps and rubella vaccine and Procarbazine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Procarbazine is a cytotoxic, immunosuppressive agent that can impair the response to vaccination. Live attenuated measles, mumps and rubella viruses may replicate excessively and cause disseminated infection.
How serious is the interaction between Measles mumps and rubella vaccine and Procarbazine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid MMR during procarbazine therapy. Vaccinate before treatment where possible, or delay until about 3 months after stopping and immune recovery is confirmed.
What other medicines interact with Measles mumps and rubella vaccine?
MediHelp also lists interactions of Measles mumps and rubella vaccine with, for example, Adalimumab, Anakinra, Antithymocyte globulin equine. The full list is on the Measles mumps and rubella vaccine page.
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