Drug interactions
Measles mumps and rubella vaccine + Ritlecitinib
Severity: Major
Measles mumps and rubella vaccine and Ritlecitinib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ritlecitinib, a JAK3/TEC kinase inhibitor, is immunosuppressive, so live MMR vaccine may cause vaccine-strain infection and response is uncertain. Labeling advises avoiding live vaccines during or shortly before treatment.
What this interaction means in plain words
Measles mumps and rubella vaccine and Ritlecitinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Measles mumps and rubella vaccine belongs to Miscellaneous; Ritlecitinib belongs to Oncology.
Why it happens
JAK3/TEC inhibition impairs lymphocyte function and cytokine signaling, reducing control of replicating attenuated virus.
What to do
Avoid MMR during ritlecitinib therapy; vaccinate before starting, ideally at least 4 weeks prior.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Measles mumps and rubella vaccine
- Adalimumab + Measles mumps and rubella vaccine Contraindicated
- Anakinra + Measles mumps and rubella vaccine Contraindicated
- Antithymocyte globulin equine + Measles mumps and rubella vaccine Contraindicated
- Antithymocyte globulin rabbit + Measles mumps and rubella vaccine Contraindicated
- Azathioprine + Measles mumps and rubella vaccine Contraindicated
- Basiliximab + Measles mumps and rubella vaccine Contraindicated
Other interactions of Ritlecitinib
- Cyclosporin + Ritlecitinib Major
- Ergotamine + Ritlecitinib Major
- Pimozide + Ritlecitinib Major
- Rifampicin + Ritlecitinib Major
- Apalutamide + Ritlecitinib Moderate
- Bendamustine + Ritlecitinib Moderate
Frequently asked questions
Can I take Measles mumps and rubella vaccine with Ritlecitinib?
MediHelp rates the interaction as major. Measles mumps and rubella vaccine and Ritlecitinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Ritlecitinib, a JAK3/TEC kinase inhibitor, is immunosuppressive, so live MMR vaccine may cause vaccine-strain infection and response is uncertain. Labeling advises avoiding live vaccines during or shortly before treatment.
How serious is the interaction between Measles mumps and rubella vaccine and Ritlecitinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid MMR during ritlecitinib therapy; vaccinate before starting, ideally at least 4 weeks prior.
What other medicines interact with Measles mumps and rubella vaccine?
MediHelp also lists interactions of Measles mumps and rubella vaccine with, for example, Adalimumab, Anakinra, Antithymocyte globulin equine. The full list is on the Measles mumps and rubella vaccine page.
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