Drug interactions
Rifampicin + Ritlecitinib
Severity: Major
Rifampicin and Ritlecitinib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rifampicin is a strong CYP3A inducer and can substantially lower ritlecitinib exposure. This may lead to loss of therapeutic effect in alopecia areata.
What this interaction means in plain words
Rifampicin and Ritlecitinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Rifampicin belongs to Anti Bacterial; Ritlecitinib belongs to Oncology.
Why it happens
Induction of CYP3A-mediated metabolism by rifampicin increases ritlecitinib clearance.
What to do
Avoid concomitant use; choose an alternative antituberculous or alopecia therapy where feasible. If rifampicin is essential, monitor for loss of response.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Ritlecitinib
Other interactions of Rifampicin
- Cabotegravir + Rifampicin Contraindicated
- Delamanid + Rifampicin Contraindicated
- Doravirine + Rifampicin Contraindicated
- Ensitrelvir + Rifampicin Contraindicated
- Fostemsavir + Rifampicin Contraindicated
- Isavuconazole + Rifampicin Contraindicated
Frequently asked questions
Can I take Rifampicin with Ritlecitinib?
MediHelp rates the interaction as major. Rifampicin and Ritlecitinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Rifampicin is a strong CYP3A inducer and can substantially lower ritlecitinib exposure. This may lead to loss of therapeutic effect in alopecia areata.
How serious is the interaction between Rifampicin and Ritlecitinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concomitant use; choose an alternative antituberculous or alopecia therapy where feasible. If rifampicin is essential, monitor for loss of response.
What other medicines interact with Ritlecitinib?
MediHelp also lists interactions of Ritlecitinib with, for example, Cyclosporin, Ergotamine, Measles mumps and rubella vaccine. The full list is on the Ritlecitinib page.
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