Drug interactions
Apalutamide + Ritlecitinib
Severity: Moderate
Apalutamide and Ritlecitinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Apalutamide may reduce ritlecitinib exposure and potentially diminish its efficacy in alopecia areata.
What this interaction means in plain words
Apalutamide and Ritlecitinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Apalutamide belongs to Endocrine; Ritlecitinib belongs to Oncology.
Why it happens
Apalutamide induces CYP3A4 and other enzymes, increasing ritlecitinib clearance.
What to do
Monitor for loss of clinical response. Consider an alternative to apalutamide where possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Apalutamide
- Apalutamide + Cabotegravir Contraindicated
- Apalutamide + Cobicistat Contraindicated
- Apalutamide + Doravirine Contraindicated
- Apalutamide + Elbasvir / grazoprevir Contraindicated
- Apalutamide + Ensitrelvir Contraindicated
- Apalutamide + Fostemsavir Contraindicated
Other interactions of Ritlecitinib
Frequently asked questions
Can I take Apalutamide with Ritlecitinib?
MediHelp rates the interaction as moderate. Apalutamide and Ritlecitinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Apalutamide may reduce ritlecitinib exposure and potentially diminish its efficacy in alopecia areata.
How serious is the interaction between Apalutamide and Ritlecitinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for loss of clinical response. Consider an alternative to apalutamide where possible.
What other medicines interact with Apalutamide?
MediHelp also lists interactions of Apalutamide with, for example, Cabotegravir, Cobicistat, Doravirine. The full list is on the Apalutamide page.
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