Drug interactions
Measles mumps rubella and varicella vaccine live + Tacrolimus
Severity: Contraindicated
Measles mumps rubella and varicella vaccine live and Tacrolimus: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
MMRV vaccine contains four live attenuated viruses. Tacrolimus impairs T-cell control of these viruses, so disseminated vaccine-strain infection is possible and vaccine response is reduced.
What this interaction means in plain words
Measles mumps rubella and varicella vaccine live and Tacrolimus are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Why it happens
Calcineurin inhibitor-induced T-cell suppression allows uncontrolled replication of live attenuated viruses.
What to do
Avoid MMRV vaccine in patients on tacrolimus. Complete live vaccinations before starting immunosuppression where feasible.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Tacrolimus
- Adenovirus types 4 and 7 live + Tacrolimus Contraindicated
- Bcg vaccine live + Tacrolimus Contraindicated
- Cidofovir + Tacrolimus Contraindicated
- Cyclosporin + Tacrolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Tacrolimus Contraindicated
- Measles mumps and rubella vaccine live + Tacrolimus Contraindicated
Frequently asked questions
Can I take Measles mumps rubella and varicella vaccine live with Tacrolimus?
MediHelp rates the interaction as contraindicated. Measles mumps rubella and varicella vaccine live and Tacrolimus are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. MMRV vaccine contains four live attenuated viruses. Tacrolimus impairs T-cell control of these viruses, so disseminated vaccine-strain infection is possible and vaccine response is reduced.
How serious is the interaction between Measles mumps rubella and varicella vaccine live and Tacrolimus?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid MMRV vaccine in patients on tacrolimus. Complete live vaccinations before starting immunosuppression where feasible.
What other medicines interact with Tacrolimus?
MediHelp also lists interactions of Tacrolimus with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Cidofovir. The full list is on the Tacrolimus page.
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