Drug interactions
Measles vaccine + Upadacitinib
Severity: Contraindicated
Measles vaccine and Upadacitinib: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Upadacitinib suppresses immune function, so a live attenuated vaccine may cause uncontrolled vaccine-virus replication and disease. The vaccine response may also be blunted.
What this interaction means in plain words
Measles vaccine and Upadacitinib are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Why it happens
JAK inhibition impairs cellular and cytokine immune responses, permitting replication of live attenuated virus.
What to do
Do not give live vaccines during upadacitinib treatment. Complete live vaccination before starting therapy in line with current guidance, and defer live vaccines after stopping until immune recovery.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Upadacitinib
- Abrocitinib + Upadacitinib Contraindicated
- Adenovirus types 4 and 7 live + Upadacitinib Contraindicated
- Baricitinib + Upadacitinib Contraindicated
- Bcg vaccine live + Upadacitinib Contraindicated
- Cyclosporine + Upadacitinib Contraindicated
- Dengue vaccine + Upadacitinib Contraindicated
Frequently asked questions
Can I take Measles vaccine with Upadacitinib?
MediHelp rates the interaction as contraindicated. Measles vaccine and Upadacitinib are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Upadacitinib suppresses immune function, so a live attenuated vaccine may cause uncontrolled vaccine-virus replication and disease. The vaccine response may also be blunted.
How serious is the interaction between Measles vaccine and Upadacitinib?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not give live vaccines during upadacitinib treatment. Complete live vaccination before starting therapy in line with current guidance, and defer live vaccines after stopping until immune recovery.
What other medicines interact with Upadacitinib?
MediHelp also lists interactions of Upadacitinib with, for example, Abrocitinib, Adenovirus types 4 and 7 live, Baricitinib. The full list is on the Upadacitinib page.
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