Drug interactions
Mecasermin + Repaglinide
Severity: Moderate
Mecasermin and Repaglinide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mecasermin has insulin-like hypoglycemic activity, and repaglinide stimulates insulin secretion. Together they can raise the risk of hypoglycemia, especially if meals are skipped.
What this interaction means in plain words
Mecasermin and Repaglinide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Mecasermin belongs to Endocrine; Repaglinide belongs to Endocrine.
Why it happens
Additive pharmacodynamic hypoglycemic effects of IGF-1 and insulin secretagogue action.
What to do
Monitor blood glucose closely, and ensure mecasermin is given with food. Consider lowering the repaglinide dose if hypoglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Mecasermin and Repaglinide, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Mecasermin
Other interactions of Repaglinide
- Gemfibrozil + Repaglinide Contraindicated
- Clarithromycin + Repaglinide Major
- Clopidogrel + Repaglinide Major
- Cobicistat + Repaglinide Major
- Cyclosporine + Repaglinide Major
- Cyclosporin + Repaglinide Major
Frequently asked questions
Can I take Mecasermin with Repaglinide?
MediHelp rates the interaction as moderate. Mecasermin and Repaglinide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Mecasermin has insulin-like hypoglycemic activity, and repaglinide stimulates insulin secretion. Together they can raise the risk of hypoglycemia, especially if meals are skipped.
How serious is the interaction between Mecasermin and Repaglinide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose closely, and ensure mecasermin is given with food. Consider lowering the repaglinide dose if hypoglycemia occurs.
What other medicines interact with Mecasermin?
MediHelp also lists interactions of Mecasermin with, for example, Gliclazide, Glyburide-metformin, Insulin degludec-insulin aspart. The full list is on the Mecasermin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
