Drug interactions
Mecasermin + Sitagliptin
Severity: Minor
Mecasermin and Sitagliptin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mecasermin can cause hypoglycemia through insulin-like effects. Sitagliptin has a glucose-dependent action and low intrinsic hypoglycemia risk, so any added effect is likely modest.
What this interaction means in plain words
Mecasermin and Sitagliptin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Mecasermin belongs to Endocrine; Sitagliptin belongs to Endocrine.
Why it happens
Additive pharmacodynamic glucose lowering via IGF-1 insulin-like action and DPP-4 inhibition-enhanced incretin effect.
What to do
Monitor blood glucose when starting the combination and give mecasermin with food. No routine dose change is needed unless hypoglycemia occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Mecasermin
Other interactions of Sitagliptin
- Albiglutide + Sitagliptin Moderate
- Amlodipine-benazepril + Sitagliptin Moderate
- Aripiprazole + Sitagliptin Moderate
- Asenapine + Sitagliptin Moderate
- Benazepril + Sitagliptin Moderate
- Captopril-hydrochlorothiazide + Sitagliptin Moderate
Frequently asked questions
Can I take Mecasermin with Sitagliptin?
MediHelp rates the interaction as minor. Mecasermin and Sitagliptin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Mecasermin can cause hypoglycemia through insulin-like effects. Sitagliptin has a glucose-dependent action and low intrinsic hypoglycemia risk, so any added effect is likely modest.
How serious is the interaction between Mecasermin and Sitagliptin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when starting the combination and give mecasermin with food. No routine dose change is needed unless hypoglycemia occurs.
What other medicines interact with Mecasermin?
MediHelp also lists interactions of Mecasermin with, for example, Gliclazide, Glyburide-metformin, Insulin degludec-insulin aspart. The full list is on the Mecasermin page.
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