Drug interactions
Mechlorethamine + Pneumococcal vaccine 13-valent
Severity: Moderate
Mechlorethamine and Pneumococcal vaccine 13-valent: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Systemic mechlorethamine is a cytotoxic alkylating agent that suppresses immune responses, which may reduce the response to pneumococcal vaccination. Protection may therefore be inadequate in treated patients.
What this interaction means in plain words
Mechlorethamine and Pneumococcal vaccine 13-valent can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Mechlorethamine belongs to Oncology; Pneumococcal vaccine 13-valent belongs to Miscellaneous.
Why it happens
Cytotoxic myelosuppression and lymphocyte depletion impair vaccine-induced antibody production.
What to do
Give the vaccine at least 2 weeks before chemotherapy when feasible. If vaccinated during or shortly before treatment, revaccinate after immune recovery.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Pneumococcal vaccine 13-valent
- Adalimumab + Pneumococcal vaccine 13-valent Moderate
- Alefacept + Pneumococcal vaccine 13-valent Moderate
- Anakinra + Pneumococcal vaccine 13-valent Moderate
- Anti-thymocyte + Pneumococcal vaccine 13-valent Moderate
- Antithymocyte globulin equine + Pneumococcal vaccine 13-valent Moderate
- Antithymocyte globulin rabbit + Pneumococcal vaccine 13-valent Moderate
Other interactions of Mechlorethamine
Frequently asked questions
Can I take Mechlorethamine with Pneumococcal vaccine 13-valent?
MediHelp rates the interaction as moderate. Mechlorethamine and Pneumococcal vaccine 13-valent can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Systemic mechlorethamine is a cytotoxic alkylating agent that suppresses immune responses, which may reduce the response to pneumococcal vaccination. Protection may therefore be inadequate in treated patients.
How serious is the interaction between Mechlorethamine and Pneumococcal vaccine 13-valent?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give the vaccine at least 2 weeks before chemotherapy when feasible. If vaccinated during or shortly before treatment, revaccinate after immune recovery.
What other medicines interact with Pneumococcal vaccine 13-valent?
MediHelp also lists interactions of Pneumococcal vaccine 13-valent with, for example, Adalimumab, Alefacept, Anakinra. The full list is on the Pneumococcal vaccine 13-valent page.
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